Table 2.
BioCarta and KEGG molecular pathways differentially expressed during relaxation.
| ID | Name | No. Genes | Function |
|---|---|---|---|
| Control BioCarta | |||
| h_cb1r | Metabolism of anandamide, an endogenous cannabinoid | 5 | Immune function; vasodilation; pain relief |
| Control KEGG | |||
| hsa03010 | Ribosome | 85 | Genetic information processing, translation |
| RMM BioCarta | |||
| h_erk* | Erk1/Erk2 Mapk signaling pathway | 22 | Cell signaling, growth, differentiation; transcription |
| h_ahsp | Hemoglobin’s chaperone | 11 | Hemoglobin synthesis/homeostasis; O2 transport |
| h_egfr_smrte | Map kinase inactivation of SMRT corepressor | 10 | Cell proliferation; apoptosis; transcription |
| h_fMLP | fMLP induced chemokine gene expression in HMC-1 cells | 30 | Immune response; chemokine activation |
| h_sppa* | Aspirin blocks signaling pathway…platelet activation** | 14 | Inhibition of platelet activation/vasoconstriction |
| h_fcer1* | Fc epsilon receptor I signaling in mast cells | 34 | Immune/inflammatory response; cytokine expression |
| h_lymphocyte | Adhesion molecules on lymphocyte | 8 | Immune/inflammatory response; cell adhesion |
| h_vip | Neuropeptides VIP and PACAP inhibit the apoptosis…*** | 20 | Immune function; inhibition of T-cell apoptosis |
| RMM KEGG | |||
| hsa03010 | Ribosome | 85 | Genetic information processing; translation |
| hsa04650* | Natural killer cell mediated cytotoxicity | 90 | Immune response; cytotoxicity, defense |
| hsa04612 | Antigen processing and presentation | 56 | Immune system; cytotoxicity |
| hsa00450* | Selenoamino acid metabolism | 25 | Amino acid metabolism |
Available at: http://www.biocarta.com/genes/index.asp and http://www.genome.jp/kegg/pathway.html. The LS or KS permutation test statistic for all pathways was <0.005. There were 8,857 genes used in the pathway analysis; 261 BioCarta and 155 KEGG pathways (416 total) were tested. Pathway IDs highlighted in bold were differentially expressed during stress and relaxation.
Erk – extracellular signal-regulated kinase; Mapk – mitogen-activated protein kinase; SMRT – silencing mediator for retinoid or thyroid-hormone receptor; fMLP – N-formyl-methionyl-leucyl-phenylalanine; HMC-1 – human mastocytoma cell line; Fc – fragment, crystallizable; VIP – vasoactive intestinal peptide; PACAP – pituitary adenylate cyclase-activating polypeptide.
Showed differential expression in a genomic study of acute stress and recovery [37];
Aspirin blocks signaling pathway involved in platelet activation;
Neuropeptides VIP and PACAP inhibit the apoptosis of activated T-cells.