Table 2. ARV EC50 values for inhibition of HIV-1 in different cell types.
EC50 (µM) +/− SEa (µM) | |||||
ARV | SVG | PFA | PBMC | MDM | |
Abacavir | 0.056±0.011 | 0.004±0.001 | 0.117±0.028 | 0.010±0.003 | |
Lamivudine | 1.448±0.204 | 0.317±0.055 | 0.315±0.107 | 0.036±0.059 | |
Stavudine | 0.578±0.189 | 5.963±0.622 | 0.179±0.061 | 0.042±0.046 | |
Zidovudine | 0.017±0.003 | 1.311±0.130 | 0.008±0.002 | 0.005±0.002 | |
Efavirenz | 0.002±0.000 | 0.002±0.000 | 0.001±0.000 | 0.001±0.000 | |
Etravirine | 0.001±0.000 | 0.001±0.000 | 0.001±0.000 | 0.001±0.000 | |
Nevirapine | 0.045±0.006 | 0.114±0.020 | 0.182±0.068 | 0.166±0.253 | |
Raltegravir | 0.004±0.001 | 0.007±0.001 | 0.003±0.001 | 0.016±0.010 |
Mean 50% effective concentration±the standard error from n = 4 independent assays.
SVG, fetal astrocyte cell line; PFA, primary fetal astrocytes; PBMC, peripheral blood mononuclear cells; MDM, monocyte-derived macrophages.