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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Schizophr Res. 2013 Mar 6;146(0):254–263. doi: 10.1016/j.schres.2013.01.037

Figure 4.

Figure 4

Dysbindin-1 deletion decreases significantly the levels of parvalbumin, AP3, syntaxin 1, syntaxin 1 pS14 and synaptotgamin-1 measured in synaptosomes of the PFC. A) Blots and histogram showing significant decreases in parvalbumin (*p< 0.001) in dys −/− mice. This result indicates that decreases in [Ca2+]i in dys −/− mice are not due to an increase in buffering. A2) Western blots show a signficnat decrease in the levels of AP3 in dys −/− mice (p< 0.01) B) Western blots showing the changes in proteins assessed in dys −/− mice. B1) Quantification of expression levels of syntaxin 1a. Dys −/− mice expressed a significant reduction the levels of syntaxin 1a (p< 0.001), B2) Levels of syntaxin1 pS14 are also significantly decreased in dys −/− mice (p< 0.001). B3) Levels of SNAP-25 were not altered in the dys −/− mice. B4) Levels of synaptotagmin 1 were significantly decreased (p< 0.001) in dys −/− mice.