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. 2013 Apr 16;8(4):e61990. doi: 10.1371/journal.pone.0061990

Figure 6. Underwater EOG response to DMP and 2-heptanone was affected by unilateral naris occlusion in TRPM5(-) epithelia.

Figure 6

A; Example traces of EOG. The responses to DMP and isoamylacetate (ISO) are depicted in red and the response to IBMX is depicted in blue. The black bars above the traces indicate when the stimuli reach the epithelia and the duration of the stimulus application ( = 1 second). B; Putative pheromones (2,5-dimethylpyrazine (DMP) and 2-heptanone (2-HEP)), diluted urine (1∶200 or 1∶100) and general odorants (lilial and isoamylacetate) were tested for underwater EOG. What is reported is the ratio of the response to the pheromone/odorant divided by the response to IBMX [odor/IBMX]. In TRPM5(+) olfactory epithelia, naris occlusion had no effect on the ratio [odor/IBMX] (p value>0.05, paired t-test, FDR corrected). However, in TRPM5(-) olfactory epithelia, naris occlusion significantly reduced the ratio [odor/IBMX] to 2-heptanone or DMP (p<0.01, paired t-test, FDR corrected). The numbers in parentheses show the number of epithelia tested. The error bars are SEM.