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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: J Am Geriatr Soc. 2013 Mar 21;61(4):525–534. doi: 10.1111/jgs.12156

FIG. 2.1. Adjusted hazard ratios (with 95%CI) for all-cause mortality by ApoE4 carrier status (M1) and dosage(M2), stratified by time-dependent cognitive status (Cognitively normal, MCI+dementia, AD)a.

FIG. 2.1

Abbreviations: AD=Alzheimer's Disease; aHR=adjusted hazard ratio;

ApoE=Apolipoprotein E; ApoE4 carrier status=having an ε4 allele; ApoE4 dosage=the number of ε4 alleles; BMI=Body Mass Index, M1: Model 1 with ApoE4carrier status as main exposure (referent category is ApoE4non-carrier), M2: Model 2 with ApoE4 dosage (1 or 2 ε4 alleles) as main exposure (referent category is ApoE4non-carrier); MCI=mild cognitive impairment.

a All models additionally adjusted for sex, first-visit age, race, education, smoking status (time-dependent) and first-visit BMI. Note that in this analysis, observations (rather than whole individuals) were restricted to the “cognitively normal” status, dementia/MCI status or AD status, thus the overlap in individuals between the three groups.