Table 2.

All-cause, cardiovascular and non-cardiovascular mortality by ApoE4 carrier status, sex and cognitive status (time-dependent)

	aHRa	95% CI	p-value
All-cause mortality	N=1,091 participants	n=336 deaths
Model 1.1: All-cause dementia and MCI
ApoE4 (carrier vs. non-carrier)	1.31	(1.02;1.68)	0.032
Dementia(+ vs. −)	1.73	(1.33;2.26)	<0.001
MCI (+ vs. −)	1.95	(1.41;2.67)	<0.001
Male	1.28	(1.00;1.64)	0.054
Model 1.2: AD, non-AD and MCI
ApoE4 (carrier vs. non-carrier)	1.30	(1.01;1.66)	0.038
AD(+ vs. −)	1.61	(1.21;2.15)	0.001
Non-AD(+ vs. −)	2.13	(1.43;3.16)	<0.001
MCI(+ vs. −)	1.94	(1.42;2.67)	<0.001
Male	1.28	(0.99;1.64)	0.056
Cardiovascular Mortality	N=1,091 participants	n=105 deaths
Model 2.1: All-cause dementia and MCI
ApoE4 (carrier vs. non-carrier)	1.54	(1.00;2.37)	0.047
Dementia(+ vs. −)	1.45	(0.90;2.33)	0.125
MCI (+ vs. −)	1.38	(0.76;2.50)	0.288
Male	0.78	(0.53;1.16)	0.225
Model 2.2: AD, non-AD and MCI
ApoE4 (carrier vs. non-carrier)	1.51	(0.98;2.33)	0.063
AD(+ vs. −)	1.17	(0.70;1.96)	0.535
Non-AD(+ vs. −)	2.52	(1.27;5.01)	0.008
MCI(+ vs. −)	1.40	(0.77;2.54)	0.268
Male	0.76	(0.51;1.13)	0.182
Non-cardiovascular	N=1,091	n=231
Mortality	participants	deaths
Model 3.1: All-cause dementia and MCI
ApoE4 (carrier vs. non-carrier)	0.86	(0.63;1.16)	0.324
Dementia(+ vs. −)	2.12	(1.53;2.93)	<0.001
MCI (+ vs. −)	2.27	(1.56;3.31)	<0.001
Male	1.39	(1.03;1.88)	0.029
Model 3.2: AD, non-AD and MCI
ApoE4 (carrier vs. non-carrier)	0.86	(0.64;1.16)	0.330
AD(+ vs. −)	2.32	(1.66;3.25)	<0.001
Non-AD(+ vs. −)	1.63	(0.93;2.83)	0.085
MCI(+ vs. −)	2.27	(1.56;3.31)	0.001
Male	1.41	(1.04;1.90)	0.025

Abbreviations: aHR=adjusted hazard ratio; ApoE=Apolipoprotein E; ApoE4 carrier status=having an ε₄ allele; ApoE4 dosage=the number of ε₄ alleles; BMI=Body Mass Index.

^aAll Cox proportional hazards and competing risk models additionally adjusted for first-visit age, race, education, smoking status (time-dependent) and first-visit BMI.