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. 2004 Feb 11;4:3. doi: 10.1186/1471-2253-4-3

Table 5.

NNT for at least 50% pain relief in postsurgical pain

Improved with Mean percent improved with


Time (hours) Drug and dose (mg) Active Placebo Relative risk (95% CI) NNT (95% CI) Placebo Active
6 Rofecoxib 50 mg 43/110 7/53 3.0 (1.4 to 6.1) 3.9 (2.6 to 7.8) 13 39
Naproxen 550 mg 20/55 7/53 2.8 (1.3 to 6.0) 4.3 (2.6 to 13) 13 36

8 Rofecoxib 50 mg 44/110 6/53 3.5 (1.6 to 7.8) 3.5 (2.4 to 6.9) 11 40
Naproxen 550 mg 18/55 6/53 2.9 (1.2 to 6.7) 4.7 (2.7 to 16) 11 33

12 Rofecoxib 50 mg 38/110 2/53 9.2 (2.3 to 37) 3.3 (2.4 to 4.9) 4 35
Naproxen 550 mg 14/55 2/53 6.8 (1.6 to 28) 4.6 (2.9 to 11) 4 25

Naproxen was given as the sodium salt