Table 3.

Pathways where the 12 genes closely interact with melanoma driver genes (BRAF, NRAS, cKIT and MITF).

No.	Pathways	Driver genes assocated pathway (BARF, NRAS, c-KIT, MITF)	IL8	FGFR3	PTPRF	TNC	SHC4	CXCL13	EGFR	WNT4	FGFR2	PPP2R2C	CHP2	COL11A1
1	hsa04010	MAPK signaling pathway		✓					✓		✓		✓
2	hsa04012	ERBB signaling pathway					✓		✓
3	hsa04060	cytokine-cytokine receptor interaction	✓					✓	✓
4	hsa04062	chemokine signaling pathway	✓				✓	✓
5	hsa04115	p53 signaling pathway
6	hsa04144	endocytosis		✓					✓		✓
7	hsa04360	axon guidance											✓
8	hsa04370	VEGF signaling pathway											✓
9	hsa04510	focal adhesion				✓	✓		✓					✓
10	hsa04530	tight junction										✓
11	hsa04540	GAP junction							✓
12	hsa04650	natural killer cell mediated cytotoxicity					✓						✓
13	hsa04660	T cell receptor signaling pathway											✓
14	hsa04662	B cell receptor signaling pathway											✓
15	hsa04720	long-term potentiation											✓
16	hsa04722	neurotrophine signaling pathway					✓
17	hsa04810	regulation of actin cytoskeleton		✓					✓		✓
18	hsa04910	insulin signaling pathway			✓		✓
19	hsa04912	GnRH signaling pathway							✓
20	hsa04916	melanogenesis								✓
21	hsa05160	hepatitis C	✓						✓			✓
22	hsa05166	HTLV-1 infection								✓
23	hsa05200	pathways in cancer	✓	✓					✓	✓	✓
24	hsa05212	pancreatic cancer							✓
25	hsa05213	endometrial cancer							✓
26	hsa05214	glioma					✓		✓
27	hsa05215	prostate cancer							✓		✓
28	hsa05218	melanoma							✓
29	hsa05219	bladder cancer	✓	✓					✓
30	hsa05220	chronic myeloid leukemia					✓
31	hsa05223	non-small cell lung cancer							✓