Table 3. Functional classification of gene transcripts significantly enriched with over-represented GO terms (corrected p<0.05).
| Gene Symbol | Fold change (compare to LEW control) | Description | ||||
| LEW | PVG | |||||
| - | +LPS | - | +LPS | |||
| LEW > PVG | ||||||
| Extracellular Region | ||||||
| PRL8A9 | 1 | 1.466 | 0.611 | 0.910 | Prolactin family 8, subfamily a, member 9 | |
| VEGFA | 1 | 1.408 | 0.821 | 0.772 | Vascular endothelial growth factor A | |
| COL12A1 | 1 | 1.014 | 0.369 | 0.326 | Procollagen, type XII, alpha 1 | |
| Endopeptidase Activity | ||||||
| CASP6 | 1 | 1.141 | 0.647 | 0.755 | Caspase 6 | |
| PVG > LEW | ||||||
| Cell Cycle | ||||||
| TGFB2 | 1 | 0.543 | 3.058 | 1.964 | Transforming growth factor, beta 2 | |
| GADD45A* | 1 | 0.451 | 0.378 | 0.247 | Growth arrest and DNA-damage-inducible 45 alpha | |
| WT1 | 1 | 0.873 | 2.710 | 2.472 | Wilms tumor 1 | |
| Metal Ion Binding | ||||||
| FHL1 | 1 | 0.712 | 2.572 | 1.274 | Four and a half LIM domains 1 | |
| ITPR1 | 1 | 0.569 | 2.272 | 1.130 | Inositol 1,4,5-triphosphate receptor 1 | |
| PLOD2 | 1 | 1.617 | 2.244 | 2.561 | Procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 | |
| Cytokine Production | ||||||
| IL1RL1 | 1 | 0.771 | 2.846 | 1.473 | Interleukin 1 receptor-like 1 | |
| IRF1 | 1 | 0.898 | 1.410 | 1.621 | Interferon regulatory factor 1 | |
| F2R | 1 | 0.871 | 1.705 | 1.423 | Coagulation factor II (thrombin) receptor | |
The over-represented GO terms and associated genes were identified from the 193 out of 596 less stringent differentially expressed genes, which has been annotated in curated miRNA database.