Table 4. Promoter enrichment analysis for overrepresentation of conserved TF binding sites within the LEW-upregulated and PVG-upregulated clusters.
| Cluster | Transcription Factor (TF) | TRANSFAC ID | p-value* | Enrichment Factor** |
| LEW up-regulated genes | ||||
| PPARG | M00515 | 0.005 | 10.96 | |
| RXRA | M00631 | 0.009 | 7.786 | |
| NFE2L2 | M00821 | 0.025 | 4.939 | |
| SREBP1 | M00749 | 0.029 | 4.672 | |
| PVG up-regulated genes | ||||
| NF-AT | M00935 | 0.001 | 7.526 | |
| EGR1 | M00243 | 0.008 | 4.280 | |
| NFE2L2 | M00821 | 0.012 | 6.934 | |
| GATA2 | M00076 | 0.019 | 8.363 | |
| MYCN | M00055 | 0.025 | 5.632 | |
| NKX2-5 | M00240 | 0.037 | 3.987 | |
The 9 TFs whose binding site profiles were significantly enriched in the 13 genes described in Table 3as well as observed in the 596 selected genes with less stringent criteria are presented.
*
P-value indicated the significance of TF motif enrichment in the gene set relative to that in the background.
**
Enrichment factor values represent the frequency of the TF motif in a gene set divided by its frequency in the background set and were calculated by PRIMA program.