Table 3. Association of non-synonymous variants with the IGS phenotype.
| Genotype | Border Collie cases | Border Collie controls | Dogs from other breeds |
| MRC1:c.2143C>T a | |||
| C/C | – | 175 | 306 |
| C/T | – | 12 | – |
| T/T | 7 | – | – |
| CUBN:c.8392delC a | |||
| C/C | – | 181 | 357 |
| C/del | – | 12 | – |
| del/del | 7 | – | – |
| CUBN:c.9215G>C | |||
| G/G | – | 64 | 218 |
| G/C | – | 87 | 93 |
| C/C | 7 | 85 | 16 |
a
We observed perfect linkage disequilibrium between the MRC1:c.2143C>T and CUBN:c.8392delC variants in a sample of 557 dogs. The slightly varying numbers in the table are due to some failed genotyping assays. A list of the control dogs and their respective breeds is given in Table S3.