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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Anesthesiology. 2012 Nov;117(5):1006–1017. doi: 10.1097/ALN.0b013e3182700ab9

Fig. 3.

Fig. 3

Loss of adrenergic ligands is sufficient to cause hypersensitivity to dexmedetomidine as assessed by LORR. Dbh−/− mice illustrate hypersensitivity relative to Dbh+/− mice in response to varying intravenous doses of dexmedetomidine. (A) Latency to loss of righting reflex and (B) Duration of LORR in Dbh−/− (red) and Dbh+/− (blue) mice (n=5–6/group). Significant genotypic effects were found for both latency to F1,35=53.40, p < 0.0001 and duration of F1,35=158.77, p < 0.0001 dexmedetomidine-induced hypnosis. * p < 0.05, ** p < 0.01, and *** p < 0.001 relative to Dbh+/− mouse latency to LORR or duration of LORR times. Bars show mean ± SEM; LORR: loss of righting reflex; Dbh: dopamine β-hydroxylase.