Adrenergic-deficient mice show no significant differences from sibling controls with respect to motor tone following intravenous dexmedetomidine administration. Box plots depict integrated electromyographic intensity (normalized to percentage of maximum during wakefulness) along with lower quartile, upper quartile, group minimum, and group maximum for (A) pre-drug baseline wakefulness, (B) minimum integrated electromyogram values, (C) the duration of time at the minimum integrated electromyogram values, (D) the slope of integrated electromyogram recovery, and (E) stabilized integrated electromyogram values post-dexmedetomidine emergence in Dbh+/− (n=12) and Dbh−/− (n=8) mice. * denotes p < 0.05 in Dbh−/− mice relative to Dbh+/− mice. iEMG: integrated electromyogram; Dbh: dopamine β-hydroxylase.