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. Author manuscript; available in PMC: 2014 Mar 7.
Published in final edited form as: Mol Cell. 2013 Mar 7;49(5):808–824. doi: 10.1016/j.molcel.2013.02.013

Figure 2. Optional subunits and chromatin features that modulate PRC2.

Figure 2

A) Domain organizations of PCLs and JARID2. B) Features of the histone H3 tail that modulate PRC2 activity. Yellow circles denote trimethylation. PRC2 trimethylates K27; this activity is inhibited by K4me3 and K36me2/3 in cis (red bars) and is stimulated by K27me3 and H3 peptide 31-42 in trans (green arrows). C) Sites within SU(Z)12 and EED subunits (labeled “S”) mediate inhibition (red bars) or stimulation (green arrows) of PRC2 enzyme activity, presumably by impacting the SET domain active site (black arrows).