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. Author manuscript; available in PMC: 2014 Mar 7.
Published in final edited form as: Mol Cell. 2013 Mar 7;49(5):808–824. doi: 10.1016/j.molcel.2013.02.013

Figure 3. Mechanisms of repression by PRC1 family complexes.

Figure 3

A) Ubiquitylation of histone H2A, normally by the PRC1 variant that includes a KDM2B/FBXL10-type subunit. It is not known how ubiquitylation impacts transcription, but inhibition has been proposed to occur after initiation. B) Compaction of the chromatin template by canonical PRC1 containing the PC/CBX and PH subunits. Compaction might occur over promoter regions, in gene bodies, or throughout the gene. C) PRC1 interacting with the general transcription factor TFIID and blocking association of the Mediator complex required for transcriptional activation.