Table 1. Microarray analysis of human blastocysts in patients undergoing in vitro fertilization and preimplantation genetic screening.
Observations | Advanced maternal age | Recurrent miscarriage | Total |
No. of cycles | 51 | 21 | 72 |
Average age | 40.2±2.8 | 33.2±2.2 | |
No. of zygote (2 pronuclei) | 375 | 197 | 572 |
No. (%)* of blastocysts biopsied | 246 (65.6) | 137 (69.5) | 383 (67.0) |
No. (%) of samples with DNA signals | 242 (98.4) | 135 (98.5) | 377 (98.4) |
No. (%) of normal embryos | 87 (36.0)a | 71 (52.6)b | 158 (41.9) |
No. (%) of abnormal embryos** | 155 (64.0)a | 64 (47.4)b | 219 (58.1) |
No. (%) of patients with embryo(s) for transfer | 33 (64.7)c | 19 (90.5)d | 52 (72.2) |
Blastocyst rate, out of zygotes (2 pronuclei).
Abnormal embryos include aneuploidy, chromosome deletions and duplications.
P<0.01 within the same row.
P<0.05.