Table 1. Parameters describing the biology of P. falciparum infection.

Parameter	Description	Value	Reference
n	mean number of successful sporozoites per challenge	150 (75–237)	estimated
σn	standard deviation of number of sporozoites	194 (93–324)	estimated
tL	duration of liver-stage development	6.5 days	Murphy et al [18]
µ	mean number of merozoites released per sporozoite	2,136 (1,834–3,606)	estimated
σµ	standard deviation in number of merozoites per sporozoite	4,460 (3,394–7,613)	estimated
m	daily blood-stage parasite multiplication rate	3.8 day−1	Bejon et al [20]
PT	threshold number of parasites for detection of infection	50,000,000 parasites	Bejon et al [41]
βab	anti-CSP titre for 50% reduction in sporozoite survival probability	6.62 (1.34–16.29) µg/mL	estimated
αab	shape parameter for antibody dose-response	1.32 (0.85–1.77)	estimated
βCMI	number of CD4+ T cells for 50% reduction in sporozoite survival probability	1,367 (795–4,662) cells/million	estimated

Estimated parameters are shown with 95% confidence intervals.