Table 4. Summary of results, including the number of inferred functions and the value resulting from a one-tailed t-test comparing the ROC AUC for predicting genetic interactions using the original functional annotations vs. the combination of original and inferred annotations.

Species	Number of novel inferred functions	Number of known inferred functions	BioGRID: ROC AUC (GOA)/ROC AUC (GOA+inferred functions)	STRING-PPI: ROC AUC (GOA)/ROC AUC (GOA+inferred functions)	PPI: ROC AUC (GOA)/ROC AUC (GOA+inferred functions)	GI: ROC AUC (GOA)/ROC AUC (GOA+inferred functions)	p-value (BioGRID)	p-value (STRING-PPI)	p-value (PPI)	p-value (GI)
Fish	1,409	679	0.835/0.915	0.717/0.738	0.835/0.889	0.902/0.952	0.204	0.044	0.218	5.1×10
Yeast	12,483	1,450	0.664/0.686	0.721/0.723	0.892/0.895	0.894/0.896	<10−6	0.130	0.243	0.334
Fly	1,057	517	0.764/0.799	0.747/0.749	0.821/0.822	0.854/0.870	4.7 × 10−4	0.357	0.475	0.088
Worm	3,885	5,336	0.763/0.791	0.801/0.814	0.794/0.828	0.806/0.851	3.1 × 10−4	4.8 × 10−5	5.5 × 10−3	8.7 × 10−5
Mouse	14,013	2,135	0.807/0.832	0.771/0.791	0.853/0.867	0.925/0.935	0.223	<10−6	9.2 × 10−3	5.9 × 10−3
Total	32,847	10,108	0.665/0.687	0.745/0.754	0.867/0.877	0.896/0.907	<10−6	<10−6	1.4 × 10−3	8.2 × 10−5