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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Mamm Genome. 2013 Feb 13;24(0):95–104. doi: 10.1007/s00335-013-9447-1

Figure 5. Haplotype analysis and refinement of cataract mutation to rat chromosome 9.

Figure 5

(A) Location of the 95% confidence interval (CI) of the genomic interval linked to the cataract mutation (solid black bar) next to the physical map (left) and haplotype analysis of the F1(SS/Jr-Ctr X SHR) X SHR population (right). The haplotype analysis provides a refinement of the QTL based on genotype and absence of cataract (haplotype 1–2) or cataract status (haplotype 3–5). Haplotype 3–5 exhibit cataracts and share the SS/Jr-Ctr/SHR genotype at 09_0059708371 (denoted by the arrow). (B) Refinement of the cataract QTL using key recombinant animals from BC. All three animals exhibited cataracts and shared the SS/Jr-Ctr allele at only microsatellite markers D9Rat85 (63,689,889 Mb) to D9Mit2 (63,839,862 Mb). The genomic interval containing the cataract mutation is denoted by the boxed area.