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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Neuropharmacology. 2012 Dec 25;78:75–80. doi: 10.1016/j.neuropharm.2012.12.005

Figure 1. Regulation of neurotransmitter phenotype expression.

Figure 1

The specification of neural progenitors by morphogenetic proteins triggers a genetic program that results in expression of transcription factors in the emerging neurons necessary for the definition of the neurotransmitter identity. This is not a rigid program because it is intersected by other developmental and environmental cues, including pre and postsynaptogenic electrical activity and factors released from target tissues. In turn, the neurotransmitter signaling feedback loops into the process of neurotransmitter specification.