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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Neurobiol Dis. 2013 Mar 5;54:94–104. doi: 10.1016/j.nbd.2013.02.015

Fig 1.

Fig 1

Somatostatin (SST) reduced the frequency of sEPSCs at Schaffer collateral-CA1 synapses. (A), Representative sEPSC recordings obtained from CA1 pyramidal neurons (CA1 neurons) before (Control) and after the application of 1 μM SST. (B), Cumulative probability plots of sEPSC frequency obtained by pooling data from 16 neurons before (—) and after (- - -) application of SST. (C), Distribution of sEPSC amplitudes binned by 1pA before (grey) and after (black) application of SST. Note that SST reduced the number of large amplitude sEPSCs. (D), Relationship of SST concentration to sEPSC frequency. Note that SST diminished the frequency of sEPSCs at lower concentrations but enhanced them at higher concentrations. The arithmetic equivalent of log dose used and their respective sample size are: 100 nM (n=3), 316 nM (n=3), 1μM (n=4), 3.16μM (n=4), 10μM (n=4), 19.9μM (n=3) and 31.6μM (n=3).