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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Neurobiol Dis. 2013 Mar 5;54:94–104. doi: 10.1016/j.nbd.2013.02.015

Fig 7.

Fig 7

The SST2R agonist octreotide prevented pilocarpine-induced status epilepticus (SE). (A, B), Representative EEG traces from the hippocampus of animals pretreated with i.c.v. saline (A) or octreotide (50 μg) (B) during pilocarpine-induced SE. (C), The relationship between various doses of octreotide and the percentage of seizure-free animals at 1 h is displayed. (D), The relationship in (C) was best approximated by a sigmoidal function (with minimum fixed to 0 and maximum set at 100%); the ED50 value of octreotide to prevent SE was 30 μg. The arithmetic doses of the log doses plotted in (D) are: 1.6μg (0.204), 5.0μg (0.699), 16.6μg (1.22), 50μg (1.699).