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. 2013 Mar 15;9:544–556. doi: 10.3762/bjoc.9.60

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Copyright © 2013, Taldone et al.

This is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)

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Scheme 1 — Reagents and conditions: (a) D-biotin, DCC, DMAP, CH₂Cl₂, sonicate; (b) EZ-Link^® NHS-LC-Biotin, DIEA, DMF, 35 °C or rt; (c) EZ-Link^® NHS-LC-LC-Biotin, DIEA, DMF, 35 °C or rt; (d) EZ-Link^® NHS-PEG₄-Biotin, DIEA, DMF, 35 °C or rt.