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The release media of different pH values which were used to simulate the alkalescent conditions in normal tissues and blood (pH∼7.4) and the acidic conditions in tumor (pH = 4∼6.8). The nano apatite-DOX hardly released DOX in the pH∼7.4 release medium (PBS), but responsively released DOX in pH 5.5 acidic media (sodium acetate). Data represent mean value ± SE (n = 3).
