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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: J Neurochem. 2012 May 17;122(1):221–229. doi: 10.1111/j.1471-4159.2012.07763.x

Figure 5. IGF-1 increased spontaneous neuronal spiking activity.

Figure 5

(a) Exemplary recording of unstimulated control CA3 pyramidal layer spontaneous electrophysiological activity. (b) Exemplary recording of 3-day IGF-1-exposed CA3 pyramidal layer spontaneous electrophysiological activity. (c) Acute IGF-1 treatment (n = 9) triggered a significant (*p = 0.03) increase in spontaneous CA3 pyramidal neuron spiking compared to control (n = 6). (d) 3-day IGF-1 treatment also (n = 7) triggered a significant (*p = 0.001) increase in spontaneous CA3 pyramidal neuron bursting compared to control (n = 6). (e) Similarly, 7-day IGF-1 treatment also (n = 6) triggered a significant (*p < 0.001) increase in spontaneous CA3 pyramidal neuron bursting compared to control (n = 7). Comparisons between groups made via ANOVA plus Holm-Sidak post hoc testing.