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. 2013 Apr 17;8(4):e61506. doi: 10.1371/journal.pone.0061506

Figure 6. Involvement of Rho/ROCK signaling pathway in the Thy-1-induced inhibition in capillary-like tube formation.

Figure 6

Over-expression of Thy-1 inhibited the capillary-like tube formation. However, co-transfection of Thy-1-transfected HUVEC with RhoA V14 prevented the Thy-1-induced inhibition of capillary-like tube formation. Treatment with 5 µM Y-27632 inhibited capillary-like formation and abolished the RhoA V14-induced prevention effect on Thy-1-mediated inhibition of capillary-like tube formation.