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. 2013 Apr 17;8(4):e61555. doi: 10.1371/journal.pone.0061555

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© 2013 Martens-de Kemp et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The level of DNA-bound platinum was determined in 17 HNSCC cell lines that were incubated with cisplatin. A significant inverse correlation was found between the platinum-DNA adducts and the IC₅₀ value. Measurements were performed in duplicate and error bars represent standard deviations.