Table 2. Cisplatin accumulation after four hours of cisplatin exposure and the percentage of cisplatin retention after three hours in drug free medium.
| HNSCC cell line | IC50 (µM) | Cisplatin accumulation (pmol cisplatin/106 cells) | Retention (%) |
| UM-SCC-6 | 1.12±0.15 | 922±56 | 70.4 |
| UM-SCC-11B | 2.48±0.16 | 153±6 | 79.6 |
| UM-SCC-14A | 3.27±0.51 | 337±12 | 69.6 |
| UM-SCC-14B | 2.35±0.70 | 242±62 | 100 |
| UM-SCC-14C | 2.60±0.17 | 91±13 | 85.9 |
| UM-SCC-22A | 0.69±0.32 | 97±30 | 100 |
| UM-SCC-22B | 0.93±0.31 | 452±9 | 74.2 |
| UM-SCC-38 | 7.57±1.25 | 373±22 | 52.6 |
| VU-SCC-040 | 1.81±0.45 | 267±10 | 20.0 |
| VU-SCC-094 | 0.91±0.13 | ND | ND |
| VU-SCC-096 | 0.99±0.46 | 588±29 | 56.5 |
| VU-SCC120 | 4.03±0.92 | 176±14 | 87.9 |
| VU-SCC-147 | 2.97±0.39 | ND | ND |
| VU-SCC-9917 | 0.99±0.12 | 258±16 | 95.5 |
| VU-SCC-OE | 1.66±0.25 | 252±51 | 98.4 |
| VU-SCC-1131 | 0.15±0.04 | 334±114 | 82.3 |
| VU-SCC-1365 | 0.80±0.18 | 275±76 | 97.3 |
| OHSU-0974 | 2.99±0.23 | 275±54 | 100 |
| FaDu | 1.83±0.10 | 285±90 | 61.2 |
Retention (%) represents the remaining cellular cisplatin concentration after three hours in drug free medium. Values are the means of at least duplicate experiments ± SEM. ND; not determined.