Table 2. Overview of data sets used in this article.

Application	No.	Description	# samples	Ref.
Lung cancer	1	MSAS (Michigan)	162	[40]
	2	MSAS (HLM)	69	[40]
	3	MSAS (DFCI)	73	[40]
	4	MSAS (MSKCC)	89	[40]
	5	Bild et al	51	[41]
	6	Tomida et al	91	[42]
	7	Takeuchi et al	81	[43]
	8	Roepman et al	49	[44]
Aging	1	WB Type 1 Diabetes	190	[49]
	2	WB ovarian cancer controls	261	[50]
	3	WB healthy PMP females	87	[51]
	4	Brain frontal cortex	132	[52]
	5	Brain temporal cortex	126	[52]
	6	Brain pons areas	123	[52]
	7	Brain cerebellum	111	[52]
Mouse liver	1	CAST×B6 females	141	[27]
	2	CAST×B6 males	100	[27]
	3	B6×C3H ApoE females	134	[24]
	4	B6×C3H ApoE males	124	[24]
	5	B6×C3H wild type females	66	[55]
	6	B6×C3H wild type males	69	[55]
	7	C3H×B6 wild type females	63	[55]
	8	C3H×B6 wild type males	66	[55]
	9	Mouse Diversity Panel	196	[56]

Column # samples lists the number of samples (after our removal of potential outliers) in each data set. MSAS, Multi-Site Adenocarcinoma Study; HLM, Moffit Cancer Center; DFCI, Dana-Farber Cancer Institute; MSKCC, Memorial Sloan-Kettering Cancer Center; WB, whole blood; PMP, postmenopausal.