Table 1. Subjects.

	Controls	MRIneg	MRIpos
Number of subjects	20	15	20
Age, [median (min-max)]	48 (27–72)	57 (32–69)	46 (20–66)
Sex [M/F]	5/15	1/14	6/14
MS type [RR/SP/PP]	–	10/3/2	12/7/1
EDSS [Median (min-max)]	–	2.50 (0.0–6.5)	3.25 (1.0–8.5)
MSSS [Median (min-max)]	–	3.65 (0.05–9.38)	3.74 (0.45–9.57)
Disease duration year [Median (min-max)]	–	16 (2–44)	13 (2–35)
Number of lesions at inclusion	–	≤2	>2
Number of MS lesions at present examination [Median (min-max)]	–	1 (0–20)	15 (4–30)
Brain Parenchymal Fraction (BPF) [Median (min-max)]	0.887 (0.787–0.938)	0.857 (0.827–0.921)	0.806 (0.719–0.869)