Table III.
Toxicity (grade 3–4).
| Adverse events | Type of therapy
|
|||
|---|---|---|---|---|
| LH-RH analogue (n=100), n=% | Anthracycline-taxanes (n=100), n=% | CMF+XRT (n=100), n=% | HDCT (n=17), n (%) | |
| Haematological | ||||
| Leukopenia | 0 | 32 | 3 | 17 (100) |
| Thrombocytopenia | 0 | 9 | 0 | 17 (100) |
| Anaemia | 0 | 9 | 0 | 4 (23) |
| Gastrointestinal | ||||
| Nausea-vomiting | 0 | 19 | 13 | 6 (35) |
| Diarrhoea | 0 | 11 | 3 | 3 (17) |
| Mucositis | 0 | 11 | 8 | 0 |
| Infection | 0 | 2 | 0 | 3 (17) |
| Neurotoxicity grade 2 | 0 | 15 | 0 | 0 |
| Alopecia | 0 | 100 | 0 | 17 (100) |
| Hot flushes | 90 | 0 | 0 | 0 |
CMF, cyclophosphamide, methotrexate, 5-fluorouracil; XRT, radiation therapy; HDCT, dose-dense chemotherapy; LH-RH, luteneizing hormone-releasing hormone.