Figure 9.

Gene set variation analysis identifies the enrichment of polyinosinic:polycytidylic acid (poly I:C) response gene sets in lung tissue from (a) chronic obstructive pulmonary disease (COPD) patients but not (b) idiopathic pulmonary fibrosis (IPF) patients. Columns represent lung tissue samples from human subjects from publicly available data sets (COPD: GSE1122; IPF: GSE10667), colored by disease status. Rows represent gene set variation analysis scores for individual poly I:C response gene signatures. Unsupervised hierarchical clustering of enrichment scores revealed two distinct subgroups of subjects distinguished by disease status, where cluster 1 consists primarily of COPD subjects while cluster 2 consists of mainly normal subjects (a); however, there was no discernable grouping of subjects according to IPF disease status (b). AAT, alpha 1-antitrypsin; AEx, acute exacerbator; UIP, usual interstitial pneumonia.