Figure 4.

Actions of XA and LY354704 in the CA1 region. (a) Representative averaged fEPSP traces recorded from the CA1 region in a single hippocampal slice experiment taken under control conditions and during application of either LY354740 (1 μM) or XA (3 mM). LY354740 had no effect on fEPSP amplitude or waveform, whereas XA reduced the amplitude of the fEPSP and produced changes in the later components of the fEPSP (see Results). For clarity, the stimulus artifacts have been truncated. (b) Time course of the effects of LY354740 (1 μM) and XA (3 mM) on the amplitude of the CA1 fEPSP. The agents were applied as indicated by the bars above the trace. (c) Average percentage reductions in fEPSPs upon application of LY354740 (1 μM) or XA (3 mM). Error bars represent the SEM; values in parentheses represent the number of recordings; ns=no significant difference from control; *P<0.05.