Table 5. Evaluation of the influence of histopathological characteristics in patients with synchronous (synPC), metachronous (metaPC) and no peritoneal carcinomatosis (noPC).
| Characteristic | Total (N=2406) | noPC (N=2150 ) | synPC (N=115 ) | metaPC (N=141 ) | Univariate P | Multivariate P (Cox) | HR (95% confidence interval) |
|---|---|---|---|---|---|---|---|
|
Stage (UICC 7) |
|
|
|
|
<0.001 |
|
— |
|
I |
549 (22.8) |
530 (24.7) |
— |
9 (6.4) |
— |
|
|
|
II |
571 (23.7) |
549 (25.5) |
— |
18 (12.8) |
— |
|
|
|
III |
607 (25.2) |
546 (25.4) |
— |
54 (38.3) |
— |
|
|
|
IV |
522 (21.7) |
371 (17.3) |
115 (100) |
40 (28.4) |
— |
|
|
|
NR |
157 (6.5) |
154 (7.2) |
— |
20 (14.2) |
— |
|
|
|
T-stage | |||||||
|
T0 |
12 (0.5) |
12 (0.6) |
0 |
0 (0) |
— |
|
|
|
T1 |
223 (9.3) |
222 (10.3) |
0 |
1 (0.7) |
T12<0.001 |
0.016 |
0.45 (0.24–0.861) |
|
T2 |
495 (20.6) |
482 (22.4) |
2 (1.7) |
11 (7.8) |
|
|
|
|
T3 |
1170 (48.6) |
1077 (50.1) |
28 (24.3) |
65 (46.1) |
0.358 |
|
|
|
T4 |
378 (15.7) |
258 (12.0) |
72 (62.6) |
48 (34.0) |
<0.001 |
<0.001 |
3.03 (2.05–4.48) |
|
Tx |
128 (5.3) |
99 (4.6) |
13 (11.3) |
16 (11.3) |
— |
— |
— |
|
N-status | |||||||
|
N0 |
1211 (50.3) |
1169 (54.4) |
11 (9.6) |
31 (22.0) |
<0.001 |
0.044 |
0.48 (0.24–0.982) |
|
N1 |
523 (21.7) |
461 (21.4) |
23 (20.0) |
39 (27.7) |
0.044 |
— |
— |
|
N2 |
490 (20.4) |
383 (17.8) |
56 (48.7) |
51 (36.2) |
<0.001 |
0.058 |
1.95 (0.98–3.86) |
|
Nx |
182 (7.6) |
137 (6.4) |
25 (21.7) |
20 (14.2) |
— |
|
|
|
Histology | |||||||
|
AdenoCA |
1811 (75.3) |
1648 (76.7) |
64 (55.7) |
99 (70.2) |
0.082 |
|
|
|
Mucinous |
349 (14.5) |
295 (13.7) |
27 (23.5) |
27 (19.1) |
0.072 |
|
|
|
Signet Ring |
29 (1.2) |
15 (0.7) |
8 (7.0) |
6 (4.3) |
0.001 |
0.300 |
0.63 (0.26–1.51) |
|
Other |
210 (8.7) |
188 (8.7) |
13 (11.3) |
9 (6.4) |
— |
|
|
|
NR |
7 (0.3) |
4 (0.2) |
3 (2.6) |
0 |
— |
|
|
|
Grading | |||||||
|
G1 |
73 (3.0) |
67 (3.1) |
4 (3.5) |
2 (1.4) |
0.253 |
|
|
|
G2 |
1602 (66.6) |
1491 (69.3) |
36 (31.3) |
75 (53.2) |
0.047 |
0.83 |
0.95 (0.58–1.54) |
|
G3 |
346 (14.4) |
288 (13.4) |
32 (27.8) |
26 (18.4) |
0.047 |
0.67 |
1.21 (0.676–1.52) |
|
G4 |
15 (0.6) |
13 (0.6) |
2 (1.7) |
0 |
— |
|
|
|
Gx |
370 (15.4) |
291 (13.5) |
41 (35.7) |
38 (26.9) |
— |
|
|
|
L invasion |
658 (41) |
557 (37.6) |
60 (87.0) |
41 (78.8) |
0.406 |
|
|
| V invasion | 196 (13.1) | 168 (11.9) | 22 (45.8) | 37 (2.5) | 0.073 | ||
Abbreviation: NR=not reported.
P-values and hazard ratios (HRs) concern noPC vs metaPC. If univariate analysis showed significant influence, a multivariate analysis (Cox regression) was performed and multivariate P-values along with HR were given.