Table 1. Characteristics of the study cohort.
| Self-reported family history | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| |
No |
Any |
1 affected family member |
>1 family member affected |
Overall |
|||||
|
Characteristic |
n |
% |
n |
% |
n |
% |
n |
% |
n |
% |
| Median age at diagnosis (interquartile range) | 60 | (54–65) | 60 | (55–65) | 60 | (55–65) | 61 | (54–65) | 60 | (54–65) |
|
Sex | ||||||||||
| Male | 5387 | 59.3 | 996 | 58.7 | 871 | 58.6 | 125 | 59.2 | 6383 | 59.2 |
| Female |
3698 |
40.7 |
701 |
41.3 |
615 |
41.4 |
86 |
40.8 |
4399 |
40.8 |
|
Site of tumour | ||||||||||
| Right colon | 2199 | 24.2 | 478 | 28.2 | 416 | 28.0 | 62 | 29.4 | 2677 | 24.8 |
| Left colon | 3299 | 36.3 | 643 | 37.9 | 566 | 38.1 | 77 | 36.5 | 3942 | 36.6 |
| Colon NOS | 581 | 6.4 | 96 | 5.7 | 84 | 5.7 | 12 | 5.7 | 677 | 6.3 |
| Rectum |
3006 |
33.1 |
480 |
28.3 |
420 |
28.3 |
60 |
28.4 |
3486 |
32.3 |
|
Dukes stage at diagnosis |
|
|
|
|
|
|
|
|
|
|
| A | 691 | 7.6 | 158 | 9.3 | 139 | 9.4 | 19 | 9.0 | 849 | 7.9 |
| B | 2630 | 28.9 | 489 | 28.8 | 416 | 28.0 | 73 | 34.6 | 3119 | 28.9 |
| C | 3734 | 41.1 | 684 | 40.3 | 601 | 40.4 | 83 | 39.3 | 4418 | 41.0 |
| D | 1010 | 11.1 | 165 | 9.7 | 148 | 10.0 | 17 | 8.1 | 1175 | 10.9 |
| Unknown |
1020 |
11.2 |
201 |
11.8 |
182 |
12.2 |
19 |
9.0 |
1221 |
11.3 |
|
Index of Multiple Deprivation income category | ||||||||||
| Most affluent | 2027 | 22.3 | 398 | 23.5 | 359 | 24.2 | 39 | 18.5 | 2425 | 22.5 |
| 2 | 2022 | 22.3 | 381 | 22.5 | 338 | 22.7 | 43 | 20.4 | 2403 | 22.3 |
| 3 | 1946 | 21.4 | 371 | 21.9 | 321 | 21.6 | 50 | 23.7 | 2317 | 21.5 |
| 4 | 1660 | 18.3 | 274 | 16.1 | 232 | 15.6 | 42 | 19.9 | 1934 | 17.9 |
| Most deprived | 1064 | 11.7 | 206 | 12.1 | 177 | 11.9 | 29 | 13.7 | 1270 | 11.8 |
| Unknown |
366 |
4.0 |
67 |
3.9 |
59 |
4.0 |
8 |
3.8 |
433 |
4.0 |
|
Multiple cancers | ||||||||||
| No | 7421 | 81.7 | 1355 | 79.8 | 1188 | 79.9 | 167 | 79.1 | 8776 | 81.4 |
| Yes |
1664 |
18.3 |
342 |
20.2 |
298 |
20.1 |
44 |
20.9 |
2006 |
18.6 |
|
Primary surgical procedure | ||||||||||
| Major resection | 7789 | 85.7 | 1470 | 86.6 | 1284 | 86.4 | 186 | 88.2 | 9259 | 85.9 |
| Minor resection | 71 | 0.8 | 16 | 0.9 | 13 | 0.9 | 3 | 1.4 | 87 | 0.8 |
| Palliative procedure | 157 | 1.7 | 21 | 1.2 | 20 | 1.3 | 1 | 0.5 | 178 | 1.7 |
| No NHS surgical procedure | 703 | 7.7 | 127 | 7.5 | 111 | 7.5 | 16 | 7.6 | 830 | 7.7 |
| No match to Hospital Episode Statistics component of NCDR |
365 |
4.0 |
63 |
3.7 |
58 |
3.9 |
5 |
2.4 |
428 |
4.0 |
|
Method of presentation |
|
|
|
|
|
|
|
|
|
|
| Elective | 7056 | 77.7 | 1334 | 78.6 | 1158 | 77.9 | 176 | 83.4 | 8390 | 77.8 |
| Emergency | 1664 | 18.3 | 300 | 17.7 | 270 | 18.2 | 30 | 14.2 | 1964 | 18.2 |
| Unknown |
365 |
4.0 |
63 |
3.7 |
58 |
3.9 |
5 |
2.4 |
428 |
4.0 |
|
Charlson co-morbidity score | ||||||||||
| 0 | 7904 | 87.0 | 1477 | 87.0 | 1287 | 86.6 | 190 | 90.0 | 9381 | 87.0 |
| 1 | 665 | 7.3 | 127 | 7.5 | 116 | 7.8 | 11 | 5.2 | 792 | 7.3 |
| 2 | 116 | 1.3 | 25 | 1.5 | 20 | 1.3 | 5 | 2.4 | 141 | 1.3 |
| ⩾3 | 35 | 0.4 | 5 | 0.3 | 5 | 0.3 | 0 | 0.0 | 40 | 0.4 |
| Unknown |
365 |
4.0 |
63 |
3.7 |
58 |
3.9 |
5 |
2.4 |
428 |
4.0 |
| Percentage 5-year survival (95%CI) |
63.8 |
(62.7–64.9) |
67.1 |
(64.5–69.6) |
66.4 |
(63.6–69.1) |
71.6 |
(64.0–77.8) |
64.3 |
(63.3–65.3) |
| Total | 9085 | 100.0 | 1697 | 100.0 | 1486 | 100.0 | 211 | 100.0 | 10782 | 100.0 |
Abbreviations: CI=confidence interval; IMD=index of multiple deprivation; NCDR=National Cancer Data Repository; NHS=National Health Service; NOS=not otherwise specified.