Table 1. Comparison of Serum Chemistry in LVS-Infected WT and IL-12Rβ2 KO Mice.
| Serum | Units | Naive | WT | IL-12Rβ2 KO |
|---|---|---|---|---|
| Glucose | mg/dl | 333.7 ± 21.1 | 151.0 ± 2.8 | 71 ± 4.6a |
| Cholesterol | Mg/dl | 71.7 ± 8.5 | 37.3 ± 3.7 | 42 ± 3.5 |
| Triglycerides | Mg/dl | 126 ± 21.8 | 54.7 ± 2.9 | 34 ± 8.9 |
| Sodium | mmol/L | 148.3 ± 9.7 | 159.3 ± 0.5 | 161 ± 0 |
| Potassium | mmol/L | 8.3 ± 1.8 | 7.6 ± 0.6 | 6.9 ± 0.2 |
| Chloride | mmol/L | 115 ± 12.7 | 128.7 ± 0.9 | 130 ± 1 |
| Creatinine | mg/dl | <0.1b | <0.1b | <0.1b |
| Blood urea nitrogen | Mg/dl | 24.7 ± 3.2 | 11 ± 1.4 | 11 ± 1.0 |
| Albumin | g/l | 3 ± 0.2 | 1.1 ± 0 | 1.0 ± 0 |
| Calcium | mmol/L | 2.5 ± 0.2 | <1.25b | 1.3 ± 0.04 |
| Magnesium | mmol/L | 1 ± 0.5 | 0.7 ± 0.03 | 0.6 ± 0.05 |
| Phosphorus | mg/dl | >9b | >9b | >9b |
| Alkaline phosphatase | U/L | 129 ± 34.7 | 46 ± 5.7 | 54 ± 18 |
| ALT | U/L | 80 ± 4.2 | 72.3 ± 23.2 | 605 ± 300a |
| AST | U/L | 327 ± 56 | 155 ± 16.3 | 866 ± 116a |
| Amylase | U/L | 917 ± 247 | 462.7 ± 27.7 | 361 ± 23.1 |
| Creatine kinase | U/L | >1000b | >1000b | >1000b |
| Lactate dehydrogenase | U/L | 911 ± 53.7 | 464 ± 54.9 | 764 ± 65.8 |
| Protein (total) | g/l | 5.3 ± 0.4 | 2.4 ± 0.05 | 2.6 ± 0.1 |
| Uric acid | mg/dl | 4.8 ± 0.3 | 3.6 ± 0.2 | 1.3 ± 0.4 |
WT and IL-12Rβ2 KO mice were infected with LVS 105 i.d., a dose that is lethal for KO mice and sublethal for WT mice. Sera were collected on Day 7 following infection and analyzed. Numbers represent the mean ± sd values of four individual mice from two independent experiments.
a
P ≤ 0.05 by Student's t-test in a comparison between WT and KO.
b
These data yielded values that were greater than or less than the range measured, as indicated.