Table 3. Comparison of Serum Antibody Levels following LVS Infection of WT or IL-12Rβ2 KO Mice.
| Mouse strain | Route | LVS dose | Antibody titer |
|||
|---|---|---|---|---|---|---|
| IgM | Total IgG | IgG1 | IgG2c | |||
| WT | i.d. | 1 × 103 | 1:1280 | 1:2560 | <1:20 | 1:2560 |
| IL-12Rβ2 KO | i.d. | 1 × 103 | 1:5120 | 1:10,240 | 1:5120 | 1:5120 |
| WT | i.n. | 1 × 101 | 1:1280 | 1:2560 | <1:20 | 1:1280 |
| IL-12Rβ2 KO | i.n. | 1 × 101 | 1:320 | 1:10,240 | 1:2560 | 1:5120 |
WT and IL-12Rβ2 KO mice were infected i.d. with 103 LVS or i.n. with 101 LVS. Sera were collected 32 days after infection, and end-point titers of specific anti-LVS antibodies were determined by ELISA.