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. Author manuscript; available in PMC: 2013 Apr 18.
Published in final edited form as: Bone Marrow Transplant. 2011 Dec 5;47(6):817–823. doi: 10.1038/bmt.2011.181

Figure 1.

Figure 1

Figure 1

Figure 1

Figure 1

Impact of receptor-ligand incompatibility in the GVH/GVL direction on overall survival (OS) in patients with myeloid malignancy undergoing T cell depleted reduced intensity conditioning related donor haploidentical transplantation. In this model, incompatibility is defined as absence of corresponding ligand in the recipient to the inhibitory KIR present in the donor. The combinations used were KIR3DL1 for HLA Bw4 alleles (figure 1A), KIR2DL1 for HLA C2 alleles (figure 1B) that are characterized by lysine at position 80 (HLA-CLys80), KIR2DL2 and KIR2DL3 for HLA C1 alleles (graph not shown because of lack of statistical significance) characterized by Asparagine at position 80 (HLA-CAsn80), and KIR3DL2 for HLA-A3 and HLA-A11 alleles (graph not shown because of lack of statistical significance). Figure 1C depicts the impact of incompatibility for any of the above locus and figure 1D depicts the impact of multiple incompatibilities.