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. Author manuscript; available in PMC: 2013 Apr 18.
Published in final edited form as: Acta Neuropathol. 2012 Feb 12;123(3):295–319. doi: 10.1007/s00401-012-0954-z

Figure 1. Pathologic Features of Neurofibroma.

Figure 1

Neurofibromas may form circumscribed masses in dermis or soft tissue with variable, white-tan appearance (a). When involving a main peripheral nerve trunk, neurofibromas cause fusiform expansion (b). Wavy nuclei and “shredded carrot” type collagen are typical (c). Diffuse neurofibroma, a less common subtype, may form large masses with infiltration of fat and numerous pseudomeissnerian corpuscles (d). S100 usually labels a subset of cells of probable schwannian origin in neurofibromas (e), while CD34 shows variable reactivity, highlighting cells of an uncertain nature (f).