Fig. 2.

KSRP^−/− genotype enhances TNF-α-induced TNF-α and IL-1β mRNA expression in astrocytes. qRT-PCR analysis of TNF-α and IL-1β in KSRP^−/− or littermate control (WT) astrocytes treated with vehicle (PBS) or TNF-α (10 ng/mL) for 24 h. All mRNA values were normalized to the housekeeping mRNA, S9, and expressed as a fold-induction over unstimulated WT astrocytes (set at a value of 1). Data points are the mean (±SEM) of at least four independent experiments. *P, < 0.05 (compared with WT).