Table 4.
Univariate Cox proportional hazard model evaluating predictors for disease progression and the necessity of repeated WLL
| Variable | Hazard ratio | CI 95% | p value | |
|---|---|---|---|---|
|
Disease progression
|
|
|
|
|
|
KL-6 U/mL (cont.) |
1.000 |
1.000 |
1.001 |
0.002 |
|
KL-6 ≥1526 U/mL (binary) |
6.284 |
1.767 |
22.352 |
0.005 |
|
Age, yrs (cont.) |
0.967 |
0.922 |
1.010 |
0.164 |
|
Gender (female=1) |
5.448 |
1.509 |
19.671 |
0.010 |
|
Smoking history (positive=1) |
27.203 |
0.087 |
8539.00 |
0.260 |
|
LDH IU/L (cont.) |
1.007 |
1.002 |
1.012 |
0.003 |
|
GM-CSF autoantibodies μg/mL (cont.) |
0.993 |
0.968 |
1.020 |
0.617 |
|
PaO2, mmHg (cont.) |
0.935 |
0.892 |
0.980 |
0.005 |
|
A-aDO2, mmHg (cont.) |
1.067 |
1.020 |
1.115 |
0.010 |
|
VC, % pred. (cont.) |
0.955 |
0.922 |
0.989 |
0.009 |
|
DLCO, % pred. (cont.) |
0.948 |
0.909 |
0.989 |
0.012 |
|
Necessity of repeated WLL
|
|
|
|
|
|
KL-6 U/mL (cont.) |
1.000 |
1.000 |
1.000 |
<0.001 |
|
KL-6 ≥2157 U/mL (binary) |
20.776 |
4.316 |
100.015 |
<0.0001 |
|
Age, yrs (cont.) |
0.934 |
0.883 |
0.989 |
0.019 |
|
Gender (female=1) |
2.910 |
0.786 |
10.769 |
0.110 |
|
Smoking history (positive=1) |
28.329 |
0.060 |
13470.548 |
0.288 |
|
LDH, IU/L (cont.) |
1.010 |
1.004 |
1.017 |
0.001 |
|
GM-CSF autoantibodies, μg/mL (cont.) |
0.996 |
0.967 |
1.025 |
0.767 |
|
PaO2, mmHg (cont.) |
0.923 |
0.875 |
0.975 |
0.004 |
|
A-aDO2, mmHg (cont.) |
1.095 |
1.032 |
1.162 |
0.003 |
|
VC, % pred. (cont.) |
0.940 |
0.906 |
0.975 |
0.001 |
| DLCO, % pred. (cont.) | 0.935 | 0.892 | 0.980 | 0.005 |
Definition of abbreviation: CI; confidence interval.