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. Author manuscript; available in PMC: 2013 Apr 18.
Published in final edited form as: Cell. 2012 Mar 2;148(5):896–907. doi: 10.1016/j.cell.2012.01.039

Figure 3. Telomerase reactivation maintains telomere length and allows tumor cells to proliferate.

Figure 3

(A) Strong telomere dysfunction-induced p53BP1 foci were presented in G3/4 mTert−/− cells (panel b), but not in G4 LSL-Tert cells (panel c). (B) Quantification of p53BP1 positive prostate tumor cells. Error bars represent s.d. for a representative experiment performed in triplicate. (C–E) Telomere dysfunction induced apoptosis and blockage of proliferation. Quantification of TUNEL positive (C), Caspase-3 activation positive (D), and Ki67 positive prostate tumor cells (E). Error bars represent s.d. for a representative experiment performed in triplicate. See also Figure S3.