Video 6. Spatiotemporal demonstration of immune response to a pair of 2-day episodes.
The upper left panel represents total cell-free HSV DNA copies per milliliter present over time. The upper right panel represents spatial spread of cell-free virus during the episode. The lower left panel represents CD8+ T-cell density within each region. The lower right panel indicates reproductive number within each region. Quantities are displayed according to a heat map adjacent to each spatial map. Areas with high CD8+ T-cell levels and low reproductive numbers do not support high-level viral production. The simulated episodes are short because virus does not spread from the initial plaque to adjacent regions with high CD8+ T-cell density and reproductive numbers less than one.
elife00288v006.f4v (1.5MB, f4v)
DOI: 10.7554/eLife.00288.032