TABLE 3.

Effect of MJ33 on indices of oxidative stress associated with lung I/R

Studies were done with isolated lungs from wild-type or NOX2 null mice. Results are mean ± S.E. for n = 3.

	TBARS	8-Isoprostanes	Protein Carbonyls	Lung Weight Wet/Dry
	nmol/mg prot
Control	74.6 ± 2.5*†	210 ± 7*†	5.07 ± 0.19*†	5.85 ± 0.04*†
I/R, wild type	136 ± 3.0†	440 ± 23†	9.25 ± 0.12†	7.35 ± 0.07†
I/R + MJ33, wild type	95.5 ± 2.1*	310 ± 5*†	7.00 ± 0.01*†	6.35 ± 0.02*
I/R, NOX2 null	82.3 ± 1.8*	250 ± 5*	6.09 ± 0.07*	6.16 ± 0.007*

Control, continuous perfusion; I/R, 1 hour ischemia followed by 1 hour reperfusion; TBARS, thiobarbituric and reactive substance.

^*P < 0.05 versus I/R, wild type; ^†P < 0.05 versus I/R, NOX2 null.