TABLE 1.

Summary of doses for protection against GTC to 41.0°C from isobolographic analysis

Clonazepam:Tiagabine (Ratio)	Clonazepam	Tiagabine	Interaction index
	Dose mg/kg (95% confidence interval)		Observed/Predicted (95% confidence interval)
Observed: Alone	0.55 (0.30–1.1)	2.0 (1.0–6.8)
2:1	0.22 (0.14–0.32)	0.33 (0.22–0.50)	0.54 (0.34–0.82)
1:1	0.11 (0.091–0.14)	0.46 (0.38–0.60)	0.44 (0.25–0.76)
1:4	0.063 (0.045–0.084)	0.85 (0.60–1.1)	0.57 (0.24–0.96)
Predicted
2:1	0.40 (0.35–0.48)	0.62 (0.55–0.74)
1:1	0.25 (0.23–0.29)	1.0 (0.97–1.2)
1:4	0.11 (0.098–0.14)	1.5 (1.3–1.9)