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Concentration-dependent modulation of E1S and E217G uptake into OATP-overexpressing cell lines by silymarin and silymarin flavonolignans. Cells were coincubated with silymarin flavonolignans (0–100 μM) and [3H]E1S (0.25 µCi/ml; 1 µM; OATP2B1) or [3H]E217G (0.25 µCi/ml; 1 µM; OATP1B1, OATP1B3) for 3 minutes at 37°C. Values are expressed as percentage of vehicle control; each value represents the mean ± range of two independent experiments performed in duplicate.
