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. Author manuscript; available in PMC: 2014 Mar 20.
Published in final edited form as: Neuron. 2013 Mar 20;77(6):1151–1162. doi: 10.1016/j.neuron.2013.01.038

Figure 4. Decreasing activity in the medio-dorsal thalamus leads to deficits in working memory.

Figure 4

(A) Task design for the T-maze based DNMS working memory task. (B) CNO-treated MDhM4D mice showed a deficit in acquisition (left panel) and took longer to reach criterion (right panel) compared to control groups (delayed task) (ANOVA followed by Newman-Keuls post-hoc analysis *p<0.05; GFP-sal n=7 GFP-CNO n=6, hM4D-sal n=12 and hM4D-CNO n=11). (C) CNO-treatment impaired DNMS performance on long delays in MDhM4D mice after task acquisition (repeated measures ANOVA, group effect *p<0.05; combined controls n=21 including 5 GFP-sal, 4 GFP-CNO and 12 hM4D-sal; hM4D-CNO n=11). (D) Decreasing MD activity does not affect acquisition of a spatial reference memory T-maze task (two-tailed t-test p=0.98; hM4D-sal n=15 and hM4D-CNO n=14). Error bars: s.e.m. See also figure S4.