Skip to main content
. Author manuscript; available in PMC: 2014 Mar 20.
Published in final edited form as: Neuron. 2013 Mar 20;77(6):1151–1162. doi: 10.1016/j.neuron.2013.01.038

Figure 5. Enhancement of thalamo-prefrontal beta synchrony during working memory performance is disrupted by low MD activity.

Figure 5

(A) Phase locking of MD cells to mPFC LFP oscillations in the beta-, theta- and gamma-frequency range as a function of task phase (sample vs choice) (repeated measures ANOVA, group x task phase interaction #p<0.05; hM4D-SAL cells n=40 (green), hM4D-CNO cells n=33 (orange); sample-choice difference in controls, **p < 0.01 by paired t-test). (B) Phase locking of MD cells to dHPC LFP oscillations in the beta-, theta- and gamma-frequency range as a function of task phase (sample vs choice) (paired t-test sample-choice difference in controls and CNO-treated MDhM4D mice, ***p < 0.001; hM4D-SAL cells n=40 (green), hM4D-CNO cells n=33 (orange)). (C) Upper panel, normalized beta-phase locking strength as a function of lag to mPFC LFP for all MD cells with significant phase-locking to the mPFC, ordered by lag at which peak strength occurs. Bottom: distribution of lags at peak phase locking strength (lag, +20 ± 1.4 ms, wilcoxon signed rank test p<0.05, n=73). Error bars: s.e.m. See also Figure S5.