Fig. 2.
Expression and constitutive activity of CAM α1A/B-AR. (A) Saturation binding was performed using [125I]-HEAT to determine the density of α1-ARs in hearts of transgenic and normal mice. *P < 0.01; #P < 0.05 (significant difference compared with normal hearts). (B) IP3 concentrations were measured in heart tissue from transgenic and normal mice and normalized to wet tissue weight. +Significant activation of IP3 over nonstimulated tissue in normal hearts. †Significance of basal IP3 over nonstimulated tissue. Data represent the mean ± S.E.M. of 4–8 mice of equal sexes.