Fig. 3.
HW/BW ratios (A), fibrosis (B), ANF/BNP levels (C), and BP (D). (A) The HW/BW ratio was determined in mice aged 6–8-months. (B) Hearts were subjected to Masson Trichrome staining and the amount of fibrosis determined through Image J analysis. (C) Total RNA from hearts were subjected to Northern blot analysis and probed for ANF and BNP mRNA. (D) Measurement of the mean carotid artery BP in conscious mice. BP studies in CAM α1B-AR are published (Zuscik et al., 2001). Data represent the mean ± S.E.M. of 4–8 mice of equal sexes. *P < 0.05 (significant difference compared with nontransgenic hearts).